It will also look at how Elizabethan playgoers made sense of the world around them, at a time of political and religious unrest and economic expansion.
"If you start thinking about Romeo and Juliet in terms of civil disorder and public knife crime, it's another important dimension. That's why Shakespeare's theatre is so edgy."
The series starts on 16 April.
British Museum Director Neil MacGregor has announced full details of a special 20-part Radio 4 series dedicated to William Shakespeare.
The project won the Art Fund Prize and spawned a bestselling book which has been translated into more than a dozen languages.
He added that Elizabethan society had a lot of parallels with 21st Century Britain.
It will be supported by an exhibition at the British Museum, which is part of the London 2012 Festival – the cultural element of the summer Olympics.
"The 1590s were extraordinary because you have an England where nobody knows what the future is going to be," Mr MacGregor said.
"This series gives us a chance to understand what life was like in the turbulent world of William Shakespeare," Mr MacGregor said.
Skip to content Skip to local navigation Skip to bbc.co.uk navigation Skip to bbc.co.uk search Help Accessibility Help 20 March 2012 Last updated at 13:49 GMT Radio 4 unveils Shakespeare series
It is hoped the series will build on the template of MacGregor's previous Radio 4 series, A History Of The World In 100 Objects.
Shakespeare's Restless World runs from 16 April – 11 May on BBC Radio 4, and will be available to listen to online and download permanently.
"Somebody said to me the thing about the partnership is we know it works now, so we're having fun with it. I hope the fun continues."
They have been collected from institutions from around the country, including Westminster Abbey and the British Library.
Speaking at the launch of the Shakespeare series, BBC director general Mark Thompson praised the collaboration between the corporation and the British Museum.
"It's amazing its taken 80 years to find each other," he said, adding that the two institutions had similar goals of "universal openness and universal appeal".
The objects featured in the programme will include a medal commemorating Sir Francis Drake's circumnavigation of the world and a fork excavated at the Rose Theatre on London's South Bank.
Shakespeare's Restless World will explore the bard's life, work and the period he lived in by examining a number of objects from the era.
"Knife crime was a big problem in Elizabethan London," he said, "and Romeo and Juliet is all about that."
Mr MacGregor said the series would discuss how Shakespeare's plays were viewed in his own lifetime, and how the public helped shape his later works.
BBC
"What was interesting about Shakespeare's theatre is, it was the first theatre written for everybody. The public theatre was the new medium in the 1590s, it's like writing for television in the 1960s."
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